194098-25-4
中文名稱
194098-25-4
英文名稱
CP-409092
CAS
194098-25-4
分子式
C17H19N3O2
分子量
297.35
MOL 文件
194098-25-4.mol
更新日期
2024/04/29 22:52:17
194098-25-4 結(jié)構(gòu)式
常見問題列表
生物活性
CP-409092 是 GABAA 受體的部分激動劑，具有抗焦慮活性。靶點
GABA A receptor
體內(nèi)研究
The pharmacokinetics of CP-409,092 following single intravenous and oral doses of 4 and 15 mg/kg, respectively, are characterized by high clearance of 169+ or -18 mL/min/kg, a volume of distribution of 8.99+ or -1.46 L/kg, and an oral bioavailability of 2.9%+ or -3%. Following oral administration of 100 mg/kg [ 14 C]CP-409,092, the total recovery is 89.1%+ or -3.2% for male rats and 89.3%+ or -0.58% for female rats.