182073-77-4
中文名稱
182073-77-4
英文名稱
N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE
CAS
182073-77-4
分子式
C18H28F3N3O5
分子量
423.43
MOL 文件
182073-77-4.mol
182073-77-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 T17288 英文別名
ZD8321N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE
L-Prolinamide, N-(methoxycarbonyl)-L-valyl-N-[(1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-
物理化學性質(zhì)
沸點573.9±50.0 °C(Predicted)
密度1.232±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)11.22±0.46(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
常見問題列表
生物活性
ZD8321 是人 Neutrophil elastase (NE) 的有效抑制劑，其 Ki 值為 13±1.7 nM。靶點
Ki: 13±1.7 nM (Neutrophil elastase)
體外研究
TNFα-activated HUVEC is dose dependently inhibited by ZD8321.The adhesion between cancer cells with high elastase activity and TNFα-activated HUVEC is also inhibited by ZD8321. Expression of cell surface E-selectin by NE stimulation is suppressed in the presence of ZD8321. The concentration of soluble E-selectin in the medium increases after adhesive reaction between neutrophils and HUVEC. This increase is also dose dependently inhibited by ZD8321.