176977-56-3
176977-56-3 結構式
基本信息
4-[6-Methoxy-2-(4-Methoxyphenyl)benzofuran-3-carbonyl]benzonitrile
4-[[6-METHOXY-2-(4-METHOXYPHENYL)-3-BENZOFURANYL]CARBONYL]BENZONITRILE
Benzonitrile,4-[[6-Methoxy-2-(4-Methoxyphenyl)-3-benzofuranyl]carbonyl]-
[6-Methoxy-2-(4-methoxyphenyl)benzo[b]furan-3-yl](4-cyanophenyl)methanone
常見問題列表
|
CB1 141 nM (Ki) |
5-HT 2 Receptor 6.4 μM (Ki) |
muscarinic receptor 2.1 μM (Ki) |
CB2 >10 μM (Ki) |
LY320135 has a relatively low affinity for the CB2 receptor (K
i
=14.9±0.4 μM) and ten other unrelated receptors.
LY320135 (1 nM-10 μM) inhibits the anandamide-mediated forskolin-stimulated cAMP accumulation in CHO cell, with an IC
50
of 734±122 nM.
LY320135 (0.1-1000 nM; 1-8 min) can reverse calcium current (I
Ca
) inhibition by WIN 55212-2 in N18 cells, with an IC
50
of 55±10 nM.
LY320135 (1 μM) prevents activation of K
ir
current by WIN 55212-2 in AtT-20-CB1 cells.
LY 320135 (0.001-1 μM) reduces CA1 injury induced by 20 min oxygen-glucose deprivation (OGD) in a concentration-dependent manner.