165377-44-6
165377-44-6 結(jié)構(gòu)式
基本信息
1-(3,4-二甲氧基苯乙基)-4-(3-苯丙基)哌嗪雙鹽酸鹽
1-(3,4-二甲氧基苯乙基)-4-(3-苯基丙基)哌嗪雙鹽酸鹽
1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪鹽酸鹽
CS-2246
SA-4503(2HCl)
Cutamesine HCl
SA 4503
SA-4503
SA4503 >=98% (HPLC)
Cutamesine hydrochloride
AGY94806 dihydrochloride
SA 4503 (dihydrochloride)
Cutamesine dihydrochloride
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-13510 | 1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪鹽酸鹽 Cutamesine dihydrochloride | 165377-44-6 | 1 mg | 337元 |
| 2025/02/08 | HY-13510 | 1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪鹽酸鹽 Cutamesine dihydrochloride | 165377-44-6 | 10mM * 1mLin DMSO | 722元 |
| 2025/02/08 | HY-13510 | 1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪鹽酸鹽 Cutamesine dihydrochloride | 165377-44-6 | 5 mg | 743元 |
常見問題列表
IC50: 17.4 nM (σ1receptor, guinea pig brain membranes)
The sigma receptor might be involved in several diseases in the central nervous system. Cutamesine, a potent σ1receptor agonist, has 103-fold higher affinity for σ1 (IC 50 =17.4 nM) than σ2 (IC 50 =1,784 nM) sites in guinea pig brain membranes. Cutamesine is 14-fold selective for σ1 (K i =4.6 nM) over σ2 (K i =63.1 nM) sites in guinea pig brain homogenates. Cutamesine protects motor neuron NSC34 cells against superoxide dismutase 1 and serum free neurotoxicity. It upregulates the phosphorylation levels of Akt and extracellular signal-regulated kinase (ERK) 1/2. Cutamesine reduces the activation of the MAPK/ERK pathway and down-regulated the ionotropic glutamate receptor, GluR1.
Cutamesine extends the survival time in the SOD1G93A mice.