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1630288-74-2

中文名稱 JAS239
英文名稱 JAS239
CAS 1630288-74-2
分子式 C31H37ClN2O2
分子量 505.1
MOL 文件 1630288-74-2.mol
1630288-74-2 結(jié)構(gòu)式 1630288-74-2 結(jié)構(gòu)式

基本信息

英文別名
JAS239
JAS239 (JAS 239

應(yīng)用領(lǐng)域

用途一
JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly. JAS239 attenuated choline phosphorylation and viability in a panel of human breast cancer cell lines. Antibody blockade prevented cellular retention of JAS239 indicating direct interaction with ChoKα independent of the choline transporters and catabolic choline pathways. In mice bearing orthotopic MCF7 breast xenografts, optical imaging with JAS239 distinguished tumors overexpressing ChoKα from their empty vector counterparts and delineated tumor margins.
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