161715-21-5
中文名稱(chēng)
泰比培南
英文名稱(chēng)
Tebipenem
CAS
161715-21-5
分子式
C16H21N3O4S2
分子量
383.49
MOL 文件
161715-21-5.mol
更新日期
2025/01/14 09:39:19
161715-21-5 結(jié)構(gòu)式
基本信息
中文別名
泰比配南泰比培南
替比培南雜質(zhì)
泰比培南四水合物
英文別名
LJC11036LJC-11036
Tebipenem
LJC 11036
Tebipenem USP/EP/BP
Tebipenem Impurity 5
Tibipenem intermediate 2
(4R,5S,6S)-3-[[1-(4,5-Dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[1-(4,5-dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, (4R,5S,6S)-
(4R,5S,6S)-3-[1-(4,5-dihydro-1,3-thiazol-2-yl)azetidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylicaci
所屬類(lèi)別
原料藥：β-內(nèi)酰胺酶抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)624.5±65.0 °C(Predicted)
密度1.75
儲(chǔ)存條件Sealed in dry,Store in freezer, under -20°C
溶解度insoluble in EtOH; ≥19.15 mg/mL in H2O with gentle warming; ≥24.9 mg/mL in DMSO
酸度系數(shù)(pKa)4.29±0.60(Predicted)
形態(tài)固體
顏色White to khaki
常見(jiàn)問(wèn)題列表
生物活性
Tebipenem 是一種可口服的廣譜的碳青霉烯類(lèi)抗生素，能夠抑制革蘭氏陽(yáng)性菌和革蘭氏陰性菌，但對(duì)綠膿桿菌無(wú)作用。體外研究
Tebipenem exhibits slow tight-binding inhibition at low micromolar concentrations versus the chromogenic substrate nitrocefin, and apparent K m and k cat values of 0.8 μM and 0.03 min -1 , respectively. Tebipenem shows potent activity against B. pseudomallei , with MIC 50 and MIC 90 values of both 2 mg/L. Tebipenem shows good activity against S. pneumoniae , with the MIC range of ≤0.25 μg/mL in all of the S. pneumoniae isolates.