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152721-37-4

中文名稱 EF-5
英文名稱 EF-5
CAS 152721-37-4
分子式 C8H7F5N4O3
分子量 302.16
MOL 文件 152721-37-4.mol
152721-37-4 結(jié)構(gòu)式 152721-37-4 結(jié)構(gòu)式

基本信息

中文別名
化合物EF-5
英文別名
EF-5
EF5 >=98% (HPLC)
1H-Imidazole-1-acetamide, 2-nitro-N-(2,2,3,3,3-pentafluoropropyl)-

物理化學性質(zhì)

密度1.66±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : 125 mg/mL (413.69 mM)
酸度系數(shù)(pKa)12.32±0.46(Predicted)
形態(tài)Solid
顏色White to off-white

圖譜信息

EF-5價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/02/05HY-U00118EF-5
EF-5
152721-37-45mg900元
2025/02/05HY-U00118EF-5
EF-5
152721-37-410mM * 1mLin DMSO990元
2025/02/05HY-U00118EF-5
EF-5
152721-37-410mg1500元

常見問題列表

生物活性
EF-5 (EF5; 2-Nitroimidazole) 是用于鑒定細胞缺氧的缺氧標記試劑。
體外研究

Overexpression of CYPOR induces similar 2- to 4-fold increases in EF-5 binding and metabolic reduction of tirapazamine and CEN-209 in SiHa and HCT116 cell lines, and similar enhancement of γH2AX formation. EF-5 binding and metabolic reduction of the prodrugs are highly correlated in a panel of 14 hypoxic tumor cell lines.

體內(nèi)研究

EF-5 binding is a promising stratification biomarker for benzotriazine-N-oxide bioreductive prodrugs. In HCT116 xenografts, CYPOR overexpression also significantly increases EF-5 binding and CEN-209 reduction, and modification of tumor hypoxia causes similar changes to the bioreductive activation of both agents, resulting in a strong correlation between EF-5 binding and CEN209-induced DNA damage at the individual tumor level. Following intravenous injection of EF-5, binding and detection using a monoclonal antibody in 9L gliomas is specific and oxygen dependent. Detection of binding using fluorescence microscopy can be performed on frozen tissues; tissue sections can be counterstained with haematoxylin and eosin for light microscopic analysis. Alternatively, the distribution of hypoxia in a tumor can be inferred by examining individual tumor cells using flow cytometric techniques.

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