145888-79-5
中文名稱(chēng)
PTP1B-IN-9
英文名稱(chēng)
(3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One
CAS
145888-79-5
分子式
C19H13Cl4NO
分子量
413.12
MOL 文件
145888-79-5.mol
更新日期
2024/12/15 19:35:18
145888-79-5 結(jié)構(gòu)式
基本信息
中文別名
化合物PTP1B-IN-9 英文別名
RAMB4PTP1B-IN-9?
(3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One
4-Piperidinone, 3,5-bis[(3,4-dichlorophenyl)methylene]-
(3E,5E)-3,5-Bis(3,4-Dichlorobenzylidene)Piperidin-4-One(WXC02309)
物理化學(xué)性質(zhì)
沸點(diǎn)607.5±55.0 °C(Predicted)
密度1.463±0.06 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度DMSO: 5 mg/mL (12.10 mM)
酸度系數(shù)(pKa)6.43±0.20(Predicted)
形態(tài)固體
顏色Light yellow to yellow
常見(jiàn)問(wèn)題列表
用途
PTP1B-IN-9用作研究用化合物。
生物活性
PTP1B-IN-9 是通過(guò)抑制 20S 蛋白酶體催化活性物質(zhì)上游泛素介導(dǎo)的蛋白質(zhì)降解而產(chǎn)生的泛素-蛋白酶體系統(tǒng) (UPS) 應(yīng)激源。PTP1B-IN-9 在不影響 20S 蛋白酶體催化活性的情況下觸發(fā)泛素蛋白酶體系統(tǒng) (UPS) 應(yīng)激反應(yīng)。體外研究
PTP1B-IN-9 (0-30 μM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively.
PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC
50
value of 2 μM.
Cell Viability Assay
| Cell Line: | Keratinocytes, SiHa, CaSki and ME180 cells |
| Concentration: | 5, 10, 15, 20, 25, 30 μM |
| Incubation Time: | 48 hours |
| Result: | Produced a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively with minimal effects on the viability of primary human keratinocytes and with IC 50 similar to the obtained with HeLa cells. |