1429651-50-2
中文名稱
無中文名稱
英文名稱
HPOB
CAS
1429651-50-2
分子式
C17H18N2O4
更新日期
2024/12/23 09:09:20
分子量
314.34
MOL 文件
1429651-50-2.mol
1429651-50-2 結(jié)構(gòu)式
基本信息
中文別名
化合物HPOBHDAC6抑制劑(HPOB)
英文別名
HPOBCS-1829
N-hydroxy-4-(2-((2-hydroxyethyl)(phenyl)amino)-2-oxoethyl)benzamide
4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide
Benzeneacetamide, 4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-
4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl- benzeneacetamide HPOB
所屬類別
生物化工：HDAC 抑制劑常見問題列表
生物活性
HPOB是一種有效的，選擇性 HDAC6抑制劑，IC50為56 nM，選擇性比對其它HDACs高30多倍。體外研究
In normal (HFS) and transformed (LNCaP, A549, and U87) cells, HPOB induces acetylation of α-tubulin, however, not histones, and inhibits cell growth, however, not viability. In HFS cells, HPOB enhances transformed cell death induced by etoposide, doxorubicin, or SAHA. HPOB also enhancing etoposide-induced transformed cell death via the apoptotic pathway in transformed cells.體內(nèi)研究
In mice bearing CWR22 human prostate cancer xenografts, HPOB (300 mg/kg/d i.p.), when in combination with SAHA, causes suppression of the growth of established tumors, while produces no significant suppression when used alone.