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138559-60-1

中文名稱 AC-ARG-ARG-TRP-TRP-CYS-ARG- NH2
CAS 138559-60-1
分子式 C45H66N18O7S
分子量 1003.19
MOL 文件 138559-60-1.mol
138559-60-1 結(jié)構(gòu)式 138559-60-1 結(jié)構(gòu)式

基本信息

英文別名
AC-RRWWCR-NH2
IL-8 INHIBITOR
IL-8 Inhibitor, Antileukinate
AC-ARG-ARG-TRP-TRP-CYS-ARG-NH2

物理化學(xué)性質(zhì)

儲(chǔ)存條件-15°C

常見(jiàn)問(wèn)題列表

生物活性
Antileukinate 是一種六肽,是有效的 CXC 趨化因子受體 (CXCR) 抑制劑。Antileukinate 能抑制中性粒細(xì)胞趨化和活化。Antileukinate 可用于急性炎癥和損傷的研究。
體外研究

Antileukinate inhibits the binding of human eotaxin to human eosinophils with an IC 50 of 8.2 μM.
Antileukinate (10-100 μM; 2 hours) significantly suppresses eosinophil chemotaxis to human eotaxin.

體內(nèi)研究

Antileukinate (52.63 mg/kg; s.c.) protectes mice against acute pancreatitis and associated lung injury.
Antileukinate (5mg/kg; s.c.) inhibits the interaction between murine eotaxin and murine eosinophil.

Animal Model: Swiss mice (20-25g)
Dosage: 52.63 mg/kg
Administration: Subcutaneous injection
Result: Reduced pancreatic edema induced by Caerulein (50 μg/kg).
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