136-16-3
中文名稱
OXYTHIAMINE HYDROCHLORIDE
英文名稱
OXYTHIAMINE HYDROCHLORIDE
CAS
136-16-3
分子式
C12H17Cl2N3O2S
分子量
338.25
MOL 文件
136-16-3.mol
更新日期
2025/01/23 11:09:01
136-16-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T12354硫胺素(維生素B1)雜質(zhì)19
英文別名
azoliumoxythiamin
oxythiamine
Hydroxythiamin
oxythiamine(1+)
OXYTHIAMINE HCL
OXYTHIAMINE HYDROCHLORIDE
Oxythiamine·HCl≥ 99% (assay)
Oxythiamine (Hydroxythiamin)
OXYTHIAMINE CHLORIDE HYDROCHLORIDE
物理化學(xué)性質(zhì)
密度1.2416 (rough estimate)
折射率1.6740 (estimate)
儲(chǔ)存條件−20°C
溶解度DMSO : 51.67 mg/mL (194.00 mM)
形態(tài)Solid
顏色White to off-white
OXYTHIAMINE HYDROCHLORIDE價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/05 | HY-107430 | Oxythiamine | 136-16-3 | 5 mg | 218元 |
| 2025/02/05 | HY-107430 | Oxythiamine | 136-16-3 | 10 mg | 350元 |
| 2025/02/05 | HY-107430 | OXYTHIAMINE HYDROCHLORIDE Oxythiamine | 136-16-3 | 10mM * 1mLin DMSO | 385元 |
常見問題列表
生物活性
Oxythiamine 是一種抗代謝物和維生素B1 (vitamin B1)拮抗劑，也是眾所周知的硫銨 (thiamine) 拮抗劑和轉(zhuǎn)酮醇酶 (transketolase) 抑制劑。靶點(diǎn)
Vitamin B1, Thiamine, Transketolase.
體外研究
Oxythiamine, an antimetabolite and a vitamin B1 antagonist, is a well-known thiamine antagonist and inhibitor of transketolase. Oxythiamine alters protein expression in a dose dependent manner. The level of alpha-enolase is increased by Oxythiamine treatment, while expression of 14-3-3 protein beta/alpha is suppressed by Oxythiamine at a stratified dose. Oxythiamine causes dynamic changes of total protein expression in time dependent fashion. Oxythiamine suppresses expression of cellular phosphor proteins significantly.