129735-01-9
中文名稱
RP-8-CPT-CAMPS
英文名稱
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
CAS
129735-01-9
分子式
C16H15ClN5O5PS2
分子量
487.88
MOL 文件
129735-01-9.mol
129735-01-9 結(jié)構(gòu)式
基本信息
英文別名
RP-8-CPT-CAMPSRP-8-CPT-CAMPS SODIUM SALT
8-(4-CHLOROPHENYLTHIO)ADENOSINE-*3',5-CYCLIC MONOPH
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER
Adenosine, 8-[(4-chlorophenyl)thio]-, cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate]
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
8-(4-chlorophenylthio)adenosine-3’,5’-cyclicmonophosphorothioate,spisomer(sp-8-cpt-camps),sodi
常見問題列表
生物活性
Rp-8-CPT-cAMPS，一種 cAMP 類似物，是 cAMP 誘導(dǎo)的依賴 cAMP 的 PKA I 和 PKA II 活化的有效和競爭性的拮抗劑。Rp-8-CPT-cAMPS 優(yōu)先選擇 RI 的位點(diǎn) A 與 RII 的位點(diǎn) B。靶點(diǎn)
PKA
體外研究
Rp-8-CPT-cAMPS (100 μM; 15 min) blocks phosphorylation of VASP by 6-Bnz-cAMP and largely reduces VASP phosphorylation by forskolin and fenoterol.
Rp-8-CPT-cAMPS (100 μM; 30 min) reduces GTP-loading of Rap1 by both 8-pCPT-2'-O-Me-cAMP and 6-Bnz-cAMP.
Rp-8-CPT-cAMPS (100 μM; 30 min) largely diminishes the augmentation of bradykinin-induced IL-8 release by the PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2'-O-Me-cAMP.
Rp-8-CPT-cAMPS (10 μM) inhibits the endothelium-dependent and -independent relaxation which induced by Venom in pre-contracted rat mesenteric artery rings.