127917-66-2
中文名稱
127917-66-2
英文名稱
N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE
CAS
127917-66-2
分子式
C12H13ClFN3OS
分子量
301.77
MOL 文件
127917-66-2.mol
更新日期
2024/12/03 15:40:34
127917-66-2 結(jié)構(gòu)式
基本信息
中文別名
化合物 T16770 英文別名
RO 41-1049 HYDROCHLORIDEN-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE
127917-66-2價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-100027A | 127917-66-2 Ro 41-1049 hydrochloride | 127917-66-2 | 5mg | 500元 |
| 2024/11/08 | HY-100027A | 127917-66-2 Ro 41-1049 hydrochloride | 127917-66-2 | 10mM * 1mLin DMSO | 550元 |
| 2024/11/08 | HY-100027A | 127917-66-2 Ro 41-1049 hydrochloride | 127917-66-2 | 10mg | 650元 |
常見問題列表
生物活性
Ro 41-1049 hydrochloride 是一種可逆的并具有選擇性的 monoamine oxidase-A (MAO-A) 抑制劑。在人額葉皮層和胎盤的膜制劑中發(fā)現(xiàn)了[3H]Ro 41-1049 的高親和力結(jié)合位點的同質(zhì)群體 (Kd 值分別為 16.5 和 64.4 nM)。靶點
MAO-A
體內(nèi)研究
Ro 41-1049 (1-50 mg/kg; intraperitoneal injection; for 3 hours; Sprague-Dawley rats) treatment inhibits dopamine metabolite formation and increases dopamine levels in a dose-dependent fashion. Pretreatment with Ro 41-1049 (20 mg/kg) significantly increases dopamine formation following L-dopa administration (100 mg/kg IP) while decreasing formation of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA).
| Animal Model: | Sprague-Dawley rats (200-240 g) |
| Dosage: | 1 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg, or 50 mg/kg |
| Administration: | Intraperitoneal injection; for 3 hours |
| Result: | Inhibited dopamine metabolite formation and increased dopamine levels in a dose-dependent fashion. Pretreatment with the concentration of 20 mg/kg significantly increased dopamine formation following L-dopa administration while decreasing formation of DOPAC and HVA. |