1229018-87-4
中文名稱
TPN171
英文名稱
TPN171
CAS
1229018-87-4
分子式
C24H35N5O3
分子量
441.57
MOL 文件
1229018-87-4.mol
更新日期
2025/02/05 16:39:30
1229018-87-4 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.20±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)8.78±0.50(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6. TPN171 is a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. TPN171 was proven to exert a longer lasting effect than sildenafil in animal models, providing a foundation for a once-daily oral administration for its clinical use.