119-04-0
119-04-0 結(jié)構(gòu)式
基本信息
新霉素溶液
新霉素標液
新霉素B六乙酸酯
硫酸弗蘭西汀(新霉素B)
actiline
framygen
Framidal
Framycin
enterfram
Francetin
Fraquinol
framycetin
NEOMYCIN B
物理化學性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-17624 | 新霉素標液 Framycetin | 119-04-0 | 25 mg (16.27 mM * 2.5 mL in 0.9% NaCl) | 500元 |
| 2025/02/08 | HY-17624 | 新霉素標液 Framycetin | 119-04-0 | 50 mg (16.27 mM * 5 mL in 0.9% NaCl) | 800元 |
| 2025/02/08 | HY-17624 | 新霉素標液 Framycetin | 119-04-0 | 100 mg (16.27 mM * 10 mL in 0.9% NaCl) | 1100元 |
常見問題列表
Ki: 35 μM (RNase P cleavage activity) and 13.5 μM (hammerhead ribozyme)
The inhibition of RNase P RNA cleavage by Framycetin (Neomycin B; Fradiomycin B) is sensitive to pH and an increase in pH suppresses the inhibition in other systems.
Framycetin targets the bacterial and human ribosome and affect translation. 5″-azido neomycin B and Framycetin selectively inhibit production of the mature miRNA, boosts a downstream protein, and inhibits invasion in HCC cell line.
Framycetin binds to a structural rather than a sequence motif of the RNA. Its primary cognate target is the decoding site of the 16S rRNA, but it also binds to the Rev-responsive element in HIV-1, group I introns, and the hammerhead ribozyme, and thus inhibits their biological function.
Framycetin induces misreading of the genetic code during translation and inhibits several ribozymes. The ribosomal target site is the 16 S rRNA 1400 to 1500 region.