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118081-34-8

中文名稱 頭孢布烯二水合物
英文名稱 Ceftibuten dihydrate
CAS 118081-34-8
分子式 C15H14N4O6S2.2H2O
分子量 446.459
MOL 文件 118081-34-8.mol
更新日期 2025/01/15 08:59:22
118081-34-8 結(jié)構(gòu)式 118081-34-8 結(jié)構(gòu)式

基本信息

中文別名
孢布烯二水合物
頭孢布烯二水合物
頭孢布坦(頭孢布烯)
頭孢布烯(頭孢布坦)
(+)-(6R,7R)-7-[2-(2-氨基-1,3-噻唑-4-基)-4-羧基-2-丁烯酰胺]]-8-氧-5-硫-1-氮雙環(huán)[4.2.0]辛-2-烯-2-羧酸二水物
英文別名
Cetb
Cedax
Seftem
D02121
Sch-39720
Cedax (tn)
Cedax-13C3
Seftem (tn)
S 7432-13C3
Ceftibuten (jp15)

物理化學(xué)性質(zhì)

熔點>180°C (dec.)
儲存條件-20°C冷凍

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS02
警示詞危險
危險性描述H225

應(yīng)用領(lǐng)域

用途1
用于合成有機原料或藥物中間體;科研單位合成研究"

常見問題列表

生物活性
Ceftibuten (Sch39720) dihydrate 是一種具有口服活性的頭孢菌素,在體外對多種革蘭氏陰性和某些革蘭氏陽性病原體具有較強的抗菌活性。
體外研究

Ceftibuten (Sch39720) is highly active against Haemophilus influenza , Escherichia coli , Klebsiella sp., and Proteus sp. and moderately active against Serratia sp. and Streptococcus pyogenes . Ceftibuten is relatively inactive against enterococci and staphylococci and is only weakly active against Pseudomonas aeruginosa and obligate anaerobes. It is also stable in the presence of most β-lactamase-producing organisms except β Bacteroides fragilis . Ceftibuten is very active against strains of the family Enterobacteriaceae (mean MIC for 90% of strains=0.25 μg/ml) but less active against Campylobacterjejuni (mean MIC for 90% of strains=16.0 μg/ml).

體內(nèi)研究

Ceftibuten, a biologically stableβ-lactam antibiotic, has been shown to be transported by the small peptide transport system, to have relatively high affinity for the carrier and to show clear stereoselective and proton-gradient dependent transport characteristics in rat intestinal brush-border membrane vesicles.

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