1143579-78-5
中文名稱
3-(1-(3-([1;1'-BIPHENYL]-4-YLAMINO)-3-OXOPROPYL)-1H-1;2;3-TRIAZOL-4-YL)-6-HYDROXY-1-METHYL-2-PHENYL-1H-INDOLE-5-CARBOXYLIC ACID
英文名稱
3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
CAS
1143579-78-5
分子式
C33H27N5O4
分子量
557.599
MOL 文件
1143579-78-5.mol
1143579-78-5 結(jié)構式
基本信息
中文別名
化合物 T27591 英文別名
II-B083-(1-(3-([1
FAP1 Inhibitor
CD45 Inhibitor V
LMWPTP Inhibitor
Lyp Inhibitor III
1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1
3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
應用領域
用途一
II-B08, also known as PTP Inhibitor XXXI, is a cell-permeable SHP2 inhibitor (IC50 = 5.5 μM). II-B08 blocks growth factor stimulated ERK1/2 activation and hematopoietic progenitor proliferation, providing supporting evidence that chemical inhibition of SHP2 may be therapeutically useful for anticancer and antileukemia treatment. X-ray crystallographic analysis of the structure of SHP2 in complex with 9 reveals molecular determinants that can be exploited for the acquisition of more potent and selective SHP2 inhibitors.