112898-15-4
中文名稱
2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙銨鹽(-20°C)
英文名稱
2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT
CAS
112898-15-4
分子式
C30H39N6O15P3
分子量
816.58
MOL 文件
112898-15-4.mol
更新日期
2024/04/17 23:13:11
112898-15-4 結(jié)構(gòu)式
基本信息
中文別名
2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙銨鹽2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙銨鹽(-20°C)
腺苷 5'-(三磷酸四氫酯) 3'-(4-苯甲?；郊姿狨? 三乙胺鹽
英文別名
benzoylbenzoyl-atpBzATP triethylammonium salt
Benzoylbenzoyl-ATP, Bz-ATP
2'(3')-o-(4-benzoylbenzoyl)adeno
BENZOYLBENZOIC ADENOSINE 5'-TRIPHOSPHATE
2'-3'-O-(4-benzoylbenzoyl)adenosine*5'-triphospha
2'-3'-O-(4-BENZOYLBENZOYL)ADENOSINE5'-TR IPHOSPHATE
benzoylbenzoyl-ATP triethylammonium salt, mixed isomers
2'(3')-o-(4-benzoylbenzoyl)adenosine 5'-triphosphate triethylammonium salt
2'(3')-O-(4-Benzoylbenzoyl)adenosine-5'-triphosphatetri(triethylammonium)salt
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C
溶解度≤14 mg/ml in DMSO
形態(tài)固體
顏色白色至灰白色
水溶解性Soluble in water (supplied pre-dissolved at a concentration of 5mM)
InChIKeyHVOVBTNCGADRTH-WBLDMZOZSA-N
2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙銨鹽(-20°C)價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-136254 | 2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙銨鹽(-20°C) BzATP triethylammonium salt | 112898-15-4 | 5mg | 1200元 |
| 2024/11/08 | HY-136254 | 2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙銨鹽(-20°C) BzATP triethylammonium salt | 112898-15-4 | 10mg | 1900元 |
| 2024/11/08 | HY-136254 | 2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙銨鹽(-20°C) BzATP triethylammonium salt | 112898-15-4 | 25mg | 3900元 |
常見問題列表
生物活性
BzATP triethylammonium salt 是一種 P2X 受體激動(dòng)劑，對 P2X1，P2X2，P2X3，P2X2/3，P2X4 和 P2X7 的 pEC50 分別為 8.74，5.26，7.10，7.50， 6.19，6.31 和 5.33。BzATP triethylammonium salt 對 P2X7 受體有效，對大鼠 P2X7 和小鼠 P2X7 的EC50 分別為 3.6 μM 和 285 μM。靶點(diǎn)
pEC50: 8.74 (P2X1), 5.26 (P2X2), 7.10 (P2X3), 6.19 (P2X2/3), 6.31 (P2X4), 5.33 (P2X7)
EC50 3.6 μM (rat P2X7); 285 μM (mouse P2X7)
體外研究
BzATP (10-1000?μM; 24?h) promotes the proliferation and migration of U87 and U251 glioma cells.
P2X7R protein expression is induced by BzATP (100?μM; 6-48?h) in human glioma cells.
Cell Proliferation Assay
| Cell Line: | U87 and U251 glioma cells |
| Concentration: | 5, 10, 50, 100, 500 and 1000?μM |
| Incubation Time: | 2, 6, 12, 24, 48 and 72?hours |
| Result: |
The proliferation of U87 and U251 glioma cell lines was significantly increased in the presence of 10-1000?uM and 100-1000?μM, respectively.
The peak of cell proliferation of both U87 and U251 cell lines was at 100?μM. The optimal incubation time is 24 hours in both U87 and U251 cells lines. |
Western Blot Analysis
| Cell Line: | U87 and U251 glioma cells |
| Concentration: | 100?μM |
| Incubation Time: | 6-48?hours |
| Result: | Induced the upregulation of P2X7R. |
體內(nèi)研究
BzATP (5?mg/kg) significantly promotes P2X7R expression in the intestines compared with intestines in the sham group and the control group after cecal ligation and puncture (CLP) induction.
| Animal Model: | Male 2-month-old C57BL/6 mice (each weighing between 20 and 25?g) |
| Dosage: | 5?mg/kg |
| Administration: | Injected through the intraperitoneal route |
| Result: | At 48?hours, mice in the treated group and control group exhibited mortalities of 91% and 86%, respectively. |