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110225-59-7

中文名稱 Hetisan-2,11,13,14-tetrol,2-acetate, (2a,11a,13R)-
CAS 110225-59-7
分子式 C22H29NO5
更新日期 2023/03/13 12:41:27
110225-59-7 結(jié)構(gòu)式 110225-59-7 結(jié)構(gòu)式

基本信息

英文別名
Hetisan-2,11,13,14-tetrol,2-acetate, (2a,11a,13R)-

常見問題列表

生物活性
Guanfu base I (Acorine) 是 Guanfu base A 的活性代謝產(chǎn)物,是從 Aconitum coreanum 中分離得到的,具有很強(qiáng)的抗心律失常的作用。
體內(nèi)研究

The pharmacokinetics of Guanfu base I in Sprague-Dawley rats is examined. The method is linear in the 0.05-20 μg/mL concentration range. The recovery of Guanfu base I is more than 80%. The intraday and interday precision, expressed as the relative standard deviation, is generally good. After intravenous injection dosing, plasma Guanfu base I concentration declined in a bi-phasic manner with a terminal elimination half-life of 2.49 hours. The total plasma clearance value is 1.46 L/h/kg. After oral dosing, the plasma Guanfu base I concentration reached a maximum within 0.5 hour. The absolute bioavailability of Guanfu base I is 71.31%.

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