1030203-81-6
中文名稱
2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide
英文名稱
2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide
CAS
1030203-81-6
分子式
C14H12ClN5O2S
分子量
349.8
MOL 文件
1030203-81-6.mol
更新日期
2025/02/06 14:55:31
1030203-81-6 結(jié)構(gòu)式
基本信息
中文別名
化合物HS38化合物 T27554
化合物HS38,10 MM DMSO 溶液
HS 38,ATP競(jìng)爭(zhēng)性DAPK和ZIPK抑制劑
2-((1-(3-氯苯基)-4-氧代-4,5-二氫-1H-吡唑并[3,4-D]嘧啶-6-基)硫基)丙酰胺
英文別名
HS38HS-38 (HS38)
HS38 >=95% (HPLC)
NASYEGAVCTZSDO-UHFFFAOYSA-N
2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide
2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-propanamide
Propanamide, 2-[[1-(3-chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-
物理化學(xué)性質(zhì)
沸點(diǎn)615.0±65.0 °C(Predicted)
密度1.65±0.1 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度DMSO：可溶5mg/mL，澄清（加熱）
酸度系數(shù)(pKa)14.95±0.50(Predicted)
形態(tài)粉末
顏色白色至米色
2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/08 | HY-15847 | 2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide HS38 | 1030203-81-6 | 5mg | 550元 |
| 2025/02/08 | HY-15847 | HS38 | 1030203-81-6 | 10 mM * 1 mLin DMSO | 605元 |
| 2025/02/08 | HY-15847 | 2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide HS38 | 1030203-81-6 | 10mg | 810元 |
常見問題列表
生物活性
HS38 是一種高效、選擇性的，ATP 競(jìng)爭(zhēng)性的 DAPK1 和 ZIPK (DAPK3) 抑制劑，Kd 值分別為 300 nM 和 280 nM。HS38 也是 PIM3 的抑制劑，其 IC50 值為 200 nM。HS38 可用于平滑肌相關(guān)疾病的研究。靶點(diǎn)
Kd: 300 nM (DAPK1), 79 nM (DAPK2), 280 nM (ZIPK), IC50: 200 nM (DAPK1), 200 nM (PIM3)
體外研究
HS38 displays high affinity toward DAPK2, with a K
d
of 79 nM. DAPK2 is not implicated in smooth muscle contractility.
HS38 significantly reduces relative RLC20 phosphorylation in both the basal and sphingosine 1-phosphate (S1P) activated states in human aortic SM cells.
HS38 reduces contractile forces generated by intact mouse aorta in aortic tissue.
HS38 reduces the contractile force, RLC20 phosphorylation, and MYPT1 phosphorylation in Ca
2+
-sensitized rabbit ileum.
Western Blot Analysis
| Cell Line: | CA-VSMCs |
| Concentration: | 10 μM |
| Incubation Time: | 40 minutes |
| Result: | Reduced relative RLC20 phosphorylation in both the basal and S1P activated states. |