| Identification | Back Directory | [Name]
R(+)-BAY K 8644 | [CAS]
98791-67-4 | [Synonyms]
R-4407
NI 105
BAY-k 4407
BAY-r-4407
(+)-BAY-K-8644
R(+)-BAY K 8644
Bay-K-8644 ((R)-(+)-)
R(+)-BAY K 8644 98% 0 C
(+/-)-BAY K 8644, 0 TO 5 °C
(R)(+)BayK8644,(R) (+) Bay K 8644
R(+)-BAY K 8644 CA2(+) CHANNEL BLOCKE
BAY-K-8644 ((R)-(+)-);R-4407;NI-105;(+)-BAY-K-8644
(+)-methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate
(4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester
(4R)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
R-(+)-1,4-DIHYDRO-2,6-DIMETHY-5-NITRO-(2-[TRIFLUOROMETHYL]-PHENYL)-3-PYRIDINE CARBOXYLIC ACID METHYL ESTER
r-(+)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
[4R,(+)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-, methyl ester, (4R)- | [Molecular Formula]
C16H15F3N2O4 | [MDL Number]
MFCD00153768 | [MOL File]
98791-67-4.mol | [Molecular Weight]
356.3 |
| Hazard Information | Back Directory | [Description]
BAY-K-8644, originally described as a modulator of potential operated calcium channels, exists as two enantiomers that have opposite actions.1,2,3 (R)-(+)-BAY-K-8644 is an L-type channel blocker that has negative inotropic and vasodilatory effects at 1 μM.4,5,3 Intracerebroventricular administration of this enantiomer has no effect on motor function in mice, whereas (S)-(−)-BAY-K-8644 impairs rotarod and motor activity, an effect that is blocked by (R)-(+)-BAY-K-8644.2 | [Uses]
(R)-(+)-Bay K 8644 is a Ca2+ channel inhibitor, whose enantiomer is a Ca2+ channel activator. | [Definition]
ChEBI: (R)-Bay-K-8644 is a methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate in which the 4-position has (R)-configuration. It is an enantiomer of a (S)-Bay-K-8644. | [Biological Activity]
L-type Ca 2+ -channel blocker with negative inotropic and vasodilatatory effects in vivo . Enantiomer showing opposite effects to the racemate (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ) and (S)-(-)- enantiomer ((4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester ). In combination with BIX-01294, helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). | [storage]
Store at +4°C |
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