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ChemicalBook--->CAS DataBase List--->97612-24-3

97612-24-3

97612-24-3 Structure

97612-24-3 Structure
IdentificationBack Directory
[Name]

FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride
[CAS]

97612-24-3
[Synonyms]

Eticlopride hydrochl
S(-)-ETICLOPRIDE HYDROCHLORIDE (POTENT A ND SELECTIVE D2 DOPAMINE
3-Chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxy-benzamidehydrochloride
FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride
[Molecular Formula]

C17H26Cl2N2O3
[MDL Number]

MFCD00055132
[MOL File]

97612-24-3.mol
[Molecular Weight]

377.31
Chemical PropertiesBack Directory
[Melting point ]

144-146 °C(Solv: acetone (67-64-1))
[storage temp. ]

Desiccate at RT
[solubility ]

H2O: soluble >10mg/mL
[form ]

powder
[color ]

off-white
[optical activity]

[α]27/D 7.2°, c = 0.3 in methanol(lit.)
[Water Solubility ]

Soluble to 100 mM in water
Safety DataBack Directory
[WGK Germany ]

3
[RTECS ]

CV2450000
Hazard InformationBack Directory
[Uses]

Dopamine receptor antagonist
[Uses]

S-(?)-Eticlopride hydrochloride has been used in astrocyte-neuron coculture and functional magnetic resonance imaging (fMRI) experiments.
[Biological Activity]

Selective dopamine D 2 /D 3 receptor antagonist (K i values are 0.50 and 0.16 nM respectively). Antipsychotic.
[Biochem/physiol Actions]

Potent and selective D2 dopamine receptor antagonist. Eticlopride is highly specific for DAD2?receptors than pimozide or haloperidol. The gene encoding the D2 dopamine receptor (DRD2) is linked with a several disorders including Parkinson′s disease, schizophrenia, and susceptibility to alcoholism.
[storage]

room temperature (desiccate)
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