| Identification | Back Directory | [Name]
NIH-12848 | [CAS]
959551-10-1 | [Synonyms]
NIH-12848
NIH-12848, >98%
NIH12848;NIH 12848
NIH-12848, 959551-10-1
4-Quinazolinamine, N-(2-thienylmethyl)-2-[2-(trifluoromethyl)phenyl]-
N-(thiophen-2-ylmethyl)-2-(2-(trifluoromethyl)phenyl)quinazolin-4-amine | [Molecular Formula]
C20H14F3N3S | [MDL Number]
MFCD30738011 | [MOL File]
959551-10-1.mol | [Molecular Weight]
385.41 |
| Chemical Properties | Back Directory | [Boiling point ]
441.6±45.0 °C(Predicted) | [density ]
1.384±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 25 mg/mL | [form ]
A crystalline solid | [pka]
5.05±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NIH-12848 is a a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, and also a potentially powerful tool for exploring the cell physiology of PI5P4Ks. Reagent in the synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amines as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer. | [Biological Activity]
Cell permeable: yes''Primary Target
PI5P4Kγ''Reversible: yes | [storage]
Store at -20°C |
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| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
| Company Name: |
BOC Sciences
|
| Tel: |
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| Website: |
https://www.bocsci.com |
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