| Identification | Back Directory | [Name]
Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)- | [CAS]
941580-60-5 | [Synonyms]
NVS-PI3-4
Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)- | [Molecular Formula]
C20H26N4O3S | [MDL Number]
MFCD28974557 | [MOL File]
941580-60-5.mol | [Molecular Weight]
402.51 |
| Chemical Properties | Back Directory | [density ]
1.211±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (621.10 mM; Need ultrasonic) | [form ]
Solid | [pka]
6.48±0.70(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Biological Activity]
NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 can be used for the research of allergies, inflammatory and cancer diseases[1][2].
NVS-PI3-4 shows an exquisite cellular selectivity for PI3Kγ. NVS-PI3-4 reduces IgE/antigen-mediated phosphorylation of PKB/Akt in p110δDA. NVS-PI3-4 (5 μM; 30 minutes; BMMCs) is not accumulate in specifically in mast cells[2]. | [storage]
Store at -20°C | [References]
[1]. Bruce I, et al. Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. Bioorg Med Chem Lett. 2012;22(17):5445-5450. [2]. Collmann E, et al. Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells’ route to allergy. J Allergy Clin Immunol. 2013;132(4):959-968. |
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