| Identification | Back Directory | [Name]
NSC 95397 | [CAS]
93718-83-3 | [Synonyms]
NSC 95397
Cdc25 Inhibitor IV, NSC 95397
2,3-BIS(2-HYDROXYETHYLTHIO)-1,4-NAPHTHALENEDIONE
2,3-BIS[(2-HYDROXYETHYL)THIO]-1,4-NAPHTHOQUINONE
2,3-BIS[(2-HYDROXYETHYL)THIOL]-1,4-NAPHTHOQUINONE
1,4-Naphthalenedione, 2,3-bis[(2-hydroxyethyl)thio]-
Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem | [Molecular Formula]
C14H14O4S2 | [MDL Number]
MFCD04040032 | [MOL File]
93718-83-3.mol | [Molecular Weight]
310.39 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO: 16 mg/mL
| [form ]
Orange solid | [color ]
orange, solid
| [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Description]
NSC 95397 (93718-83-3) is a potent and selective inhibitor of Cdc25 phosphatase (Ki? = 32, 96 and 40 nM for Cdc25A, B and C respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.1 Induces cell cycle arrest, phosphorylation of EGFR and activation of ERK-1 and -2.2 Inhibits carboxyl-terminal binding protein a transcriptional corepressor that suppresses multiple pro-apoptotic and epithelial genes.3 Induces eryptosis in human erythrocytes.4 | [Uses]
NSC 95397 is a quinone-based Cdc25 inhibitor, caspase-3 activator, ERK activator, and MKP inhibitor. | [Definition]
ChEBI: 2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione is a member of 1,4-naphthoquinones. | [Biological Activity]
Potent and selective irreversible inhibitor of Cdc25 dual specificity phosphatases (K i values are 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). Displays 125-180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Inhibits carcinoma cell growth and blocks G 2 /M phase transition in vitro . | [Biochem/physiol Actions]
Irreversible Cdc25 dual specificity phosphatase inhibitor. | [storage]
Desiccate at -20°C | [References]
1) Lazo et al. (2002), Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors; Mol. Pharmacol., 61 720
2) Melchheier et al. (2005), Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation; Biochem. Biophys. Res. Commun., 327 1016
3) Blevins et al. (2015), Small Molecule, NSC95397, inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression; J. Biomol. Screen., 20 663
4) Jemaa et al. (2016), Stimulation of Suicidal Erythrocyte Death by the CDC25 Inhibitor NSC-95397; Cell. Physiol. Biochem., 40 597 |
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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