| Identification | Back Directory | [Name]
(6-[2-(2-HYDROXY-ETHYLAMINO)-9-ISOPROPYL-9H-PURIN-6-YLAMINO]-HEXYL)-CARBAMIC ACID TERT-BUTYL ESTER | [CAS]
926319-75-7 | [Synonyms]
CK59
CK-59
CK 59
(6-[2-(2-HYDROXY-ETHYLAMINO)-9-ISOPROPYL-9H-PURIN-6-YLAMINO]-HEXYL)-CARBAMIC ACID TERT-BUTYL ESTER | [Molecular Formula]
C21H37N7O3 | [MDL Number]
MFCD11856052 | [MOL File]
926319-75-7.mol | [Molecular Weight]
435.56 |
| Hazard Information | Back Directory | [Description]
CK59 is calcium-calmodulin-dependent kinase II (CaMKII) inhibitor. CK59 inhibits multiple voltage-gated calcium channels, including the L-type channel during depolarization in a dose-dependent manner. The IC50 for CK59 was approximately 50 μM, which is only fivefold larger than the reported IC50 values for CaMKII inhibition. The inhibition due to CK59 was reversible; washout of the drug brought calcium levels back to control values upon depolarization. |
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