| Identification | Back Directory | [Name]
2-(2-(2-AMINOETHOXY)ETHOXY)ETHANOL HYDROCHLORIDE | [CAS]
92505-84-5 | [Synonyms]
HO-(CH2CH2O)3-NH2 HCl
Amino-PEG3-alcohol HCl
NH2-PEG3 (hydrochloride)
2-[(2-aminoethoxy)ethoxy]ethanol hydrochloride
2-(2-(2-AMINOETHOXY)ETHOXY)ETHANOL HYDROCHLORIDE
Ethanol, 2-[2-(2-aminoethoxy)ethoxy]-, hydrochloride | [Molecular Formula]
C6H16ClNO3 | [MDL Number]
MFCD28963473 | [MOL File]
92505-84-5.mol | [Molecular Weight]
185.649 |
| Hazard Information | Back Directory | [Biological Activity]
NH2-PEG3 hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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