| Identification | Back Directory | [Name]
2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol | [CAS]
906440-37-7 | [Synonyms]
SMBA 1
SMBA1 >=98% (HPLC)
2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol
Phenol, 2-[(2-nitro-9H-fluoren-9-ylidene)methyl]- | [Molecular Formula]
C20H13NO3 | [MDL Number]
MFCD29079013 | [MOL File]
906440-37-7.mol | [Molecular Weight]
315.32 |
| Chemical Properties | Back Directory | [Boiling point ]
502.0±38.0 °C(Predicted) | [density ]
1.392±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
powder | [pka]
9.22±0.30(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
SMBA 1 is a small molecule Bax agonist. | [Biological Activity]
SMBA1 is an anti-tumor agent. It exhibits anti-proliferative effects against glioblastoma (GBM) cells.''Small-molecule Bax agonists 1 (SMBA1) is a potent and selective Bax agonist th at binds to Baxinduces conformational change which blocks Bax S184 phosphorylation. SMBA1 induces apoptosis in cancer cells and suppresses lung tumor growth in vivo without significant normal tissue toxicity. SMBA1 does not bind to other B-cell lymphoma 2 (Bcl-2) family members. | [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|