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ChemicalBook--->CAS DataBase List--->902688-24-8

902688-24-8

902688-24-8 Structure

902688-24-8 Structure
IdentificationBack Directory
[Name]

Qstatin
[CAS]

902688-24-8
[Synonyms]

Qstatin
1H-Pyrazole, 1-[(5-bromo-2-thienyl)sulfonyl]-
[Molecular Formula]

C7H5BrN2O2S2
[MOL File]

902688-24-8.mol
[Molecular Weight]

293.16
Chemical PropertiesBack Directory
[Boiling point ]

446.3±55.0 °C(Predicted)
[density ]

1.93±0.1 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,2-8°C
[solubility ]

DMSO:83.33(Max Conc. mg/mL);284.25(Max Conc. mM)
[form ]

A solid
[pka]

-5.76±0.19(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

QStatin is a potent and selective inhibitor of SmcR (V. harveyi LuxR homologue) with an EC50 of 208.9 nM, binding tightly to SmcR and changes the flexibility of the protein, thereby altering its transcription regulatory activity. QStatin shows pan-QS (Vibrio quorum sensing) inhibitor activity in diverse Vibrio species and attenuates their virulence in an aquatic host. QStatin may be a sustainable antivibriosis agent useful in aquacultures[1].
[storage]

4°C, protect from light
[References]

[1] Kim BS, et al. QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species. MBio. 2018 Jan 30;9(1). pii: e02262-17. DOI:10.1128/mBio.02262-17
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