| Identification | Back Directory | [Name]
Polyhexamethyleneguanidine phosphate | [CAS]
89697-78-9 | [Synonyms]
PHMG phosphate
POLYHEXAMETHYLENE GUANIDINE PHOSPHATE
Poly(iminoimidocarbonyliminohexamethylene) phosphate
PHMG phosphate/ Polyhexamethyleneguanidine phosphate | [Molecular Formula]
C21H45N9X2.3H3O4P | [MDL Number]
MFCD01742719 | [MOL File]
89697-78-9.mol | [Molecular Weight]
717.631 |
| Hazard Information | Back Directory | [Uses]
Polyhexamethyleneguanidine phosphate (PHMG-P) has been widely used as a disinfectant because of its strong bactericidal activity and low toxicity. | [Toxicity evaluation]
Administration of PHMG-P induced proinflammatory cytokines elevation and infiltration of immune cells into the lungs. Histopathological analysis revealed a dose-dependent exacerbation of both inflammation and pulmonary fibrosis on day 14. PHMG-P also decreased the total cell number and the CD4+/CD8+ cell ratio in the thymus, with the histopathological examination indicating severe reduction of cortex and medulla. The mRNA levels of biomarkers associated with T cell development also decreased markedly. These findings suggest that exposure of lung tissue to PHMG-P leads to pulmonary inflammation and fibrosis as well as thymic atrophy. |
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