| Identification | Back Directory | [Name]
3BDO | [CAS]
890405-51-3 | [Synonyms]
3BDO
3BDO >=98% (HPLC)
3BDO, 97%, Activator for mTOR, Autophagy inhibitor
Pentonic acid, 2,3-dideoxy-5-O-(2-nitrophenyl)-2-(phenylmethyl)-, γ-lactone | [Molecular Formula]
C18H17NO5 | [MDL Number]
MFCD30187363 | [MOL File]
890405-51-3.mol | [Molecular Weight]
327.33 |
| Hazard Information | Back Directory | [Uses]
3BDO has been used to investigate the potential effects of metformin on inflammatory lung injury. | [Biochem/physiol Actions]
3BDO is a cell-permeable, orally bioavailable, non-toxic butyrolactone derivative that is shown to competitively bind FKBP1A (FK506-binding protein 1A, 12 kDa) in a reversible manner, and suppress autophagy via the mTOR pathway. 3BDO inhibits both LPS- and oxLDL-induced autophagy in HUVECs, increases TIA1 phosphorylation, and reduces autophagosomes number. It is reported to be brain permeant, and significantly decreases atherosclerosis development in apoE-/-?mice (100 mg/kg, q.d., p.o.). 3BDO increases IDE and neprilysin levels, lowers amyloid-β deposition in an AβPP/PS1 transgenic mouse model of Alzheimer′s disease, and alleviates memory deficits. |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|