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ChemicalBook--->CAS DataBase List--->88930-15-8

88930-15-8

88930-15-8 Structure

88930-15-8 Structure
IdentificationBack Directory
[Name]

(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol
[CAS]

88930-15-8
[Synonyms]

Mogrol
Mogrol, >98%
(24R)-Cucurbit-5-ene-3β,11α,24,25-tetrol
(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol
(10α,24R)-3β,11α,24,25-Tetrahydroxy-9β-methyl-19-norlanosta-5-ene
[Molecular Formula]

C30H52O4
[MDL Number]

MFCD29904541
[MOL File]

88930-15-8.mol
[Molecular Weight]

476.73
Questions And AnswerBack Directory
[Appearance]

Constit. of Cucurbita foeridissimia (buffalo gourd).Amorph. powder.
Chemical PropertiesBack Directory
[Boiling point ]

595.6±50.0 °C(Predicted)
[density ]

1.10±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

14.67±0.29(Predicted)
[color ]

White to off-white
[CAS DataBase Reference]

88930-15-8
Safety DataBack Directory
[HS Code ]

2934999090
Hazard InformationBack Directory
[Definition]

ChEBI: Mogrol is a tetracyclic triterpenoid that is cucurbitadienol in which the side-chain double bond (position 24-25) has undergone formal oxidation to introduce hydroxy groups at positions 24 and 25 (the 24R stereoisomer). It is a biometabolite of mogrosides found in Siraitia grosvenorii. It has a role as an antineoplastic agent. It is a tetracyclic triterpenoid and a hydroxy seco-steroid. It is functionally related to a cucurbitadienol.
[Biochem/physiol Actions]

Mogrol is an aglycone of mogrosides from Siraitia grosvenorii that exhibits neuroprotective and anticancer activities. It induces apoptosis in K562 leukemia cells through suppression of ERK1/2 and STAT3 pathways. Mogrol appears to ameliorate the memory impairment caused by Aβ1-42 in mice. Mogrol increases AMPK activity in hepatocytes and suppresses adipocyte differentiation in 3T3-L1 cells.
[storage]

Store at -20°C
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