| Identification | Back Directory | [Name]
SPD-304 | [CAS]
869998-49-2 | [Synonyms]
SPD-304
CS-2594
CAY10500
SPD-304 Exclusive
6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one
4H-1-Benzopyran-4-one, 6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]- | [Molecular Formula]
C32H32F3N3O2 | [MDL Number]
MFCD31750784 | [MOL File]
869998-49-2.mol | [Molecular Weight]
547.61 |
| Chemical Properties | Back Directory | [Boiling point ]
589.2±50.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMF: 1 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml | [form ]
A crystalline solid | [pka]
7.65±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SPD304 has been used in the inhibition of tumor necrosis factor receptor 1 (TNFR1) in dorsal root ganglion neurons and tumor necrosis factor alpha in colonic epithelial cell lines. | [Biochem/physiol Actions]
SPD304 is a small molecule inhibitor of TNF-a activity with a novel mechanism of action. It interferes with protein-protein interactions on the contact surfaces of the trimeric TNF-a subunits, displacing one of the trimer units, resulting in dissociation of the trimer and loss of activity at the receptor TNFR1. SPD304 inhibits TNFR1 receptor binding to TNF-a with an IC50 of 22μM in vitro and inhibits TNF-a-mediated stimulation of IkB degradation in HeLa cells with an IC50 of 4.6 μM. | [in vivo]
SPD304 cannot be used in vivo due to its high toxicity[3]. |
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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