| Identification | Back Directory | [Name]
T-26c | [CAS]
869296-13-9 | [Synonyms]
T-26c
CPD1612
T-26c >=98% (HPLC)
Benzoic acid, 4-[[[1,4-dihydro-2-[[[(3-methoxyphenyl)methyl]amino]carbonyl]-4-oxothieno[2,3-d]pyrimidin-5-yl]methoxy]methyl]- | [Molecular Formula]
C24H21N3O6S | [MDL Number]
MFCD31558511 | [MOL File]
869296-13-9.mol | [Molecular Weight]
479.51 |
| Hazard Information | Back Directory | [Uses]
T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes[1]. | [Biological Activity]
T-26c is a highly potentselective and cell-permeable matrix metalloproteinases 13 (MMP-13) inhibitor. T-26c inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1b and oncostatin M stimulated cartilage. For full characterization detailsplease visit the T-26c probe summary on the Structural Genomics Consortium (SGC) website.
To learn about other SGC chemical probes for protein targetsvisit sigma.com/sgc | [in vivo]
T-26c is well absorbed in all species at the oral dose of 10–20 mg/kg. Oral administration of the disodium salt formulations of T-26c to guinea pigs results in significant increases in AUC (8357 ng h/mL) and Cmax (1445 ng/ mL) compared with those of the free acid T-26c (AUC = 6478 ng h/ mL and Cmax= 911 ng/mL)[1]. | [References]
[1] Nara H, et al. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site. Bioorg Med Chem. 2014 Oct 1;22(19):5487-505. DOI:10.1016/j.bmc.2014.07.025 |
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