| Identification | Back Directory | [Name]
7-MORPHOLIN-4-YL-BENZO[1,2,5]OXADIAZOL-4-YLAMINE | [CAS]
842964-18-5 | [Synonyms]
5LUB
AKOS B014392
TIMTEC-BB SBB007057
ART-CHEM-BB B014392
δ-Secretase inhibitor 11
7-morpholin-4-yl-2,1,3-benzoxadiazol-4-amine
7-MORPHOLIN-4-YL-BENZO[1,2,5]OXADIAZOL-4-YLAMINE | [Molecular Formula]
C10H12N4O2 | [MDL Number]
MFCD03422529 | [MOL File]
842964-18-5.mol | [Molecular Weight]
220.23 |
| Chemical Properties | Back Directory | [Boiling point ]
455.4±55.0 °C(Predicted) | [density ]
1.390±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (567.59 mM; Need ultrasonic) | [form ]
Solid | [pka]
1.91±0.25(Predicted) | [color ]
Brown to dark brown |
| Hazard Information | Back Directory | [Biological Activity]
Compound 11 (CP11) is an orally active and brain-penetrant delta-secretase (δ-secretase; AEP) inhibitor th at selectively blocks AEP (IC50 = 710 nM) but not other related cysteine proteases (Caspase-3/-8 IC50 = 31.86/86.71 μMCathepsin-S/-L IC50 >200 μM) via a dual active site-directed and allosteric mode of inhibition. CP11 inhibits Pala cellular AEP activity in cultures (IC50 = 800 nM) and improves cognitive functions in murine models of Alzheimerμs disease (AD) in vivo (10 mg/kg tau P301S or 5xFAD mice via daily p.o.) by reducing tau and APP cleavageameliorating synapse loss and augmenting long-term potentiation. | [storage]
Store at -20°C |
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