| Chemical Properties | Back Directory | [Boiling point ]
627.1±55.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 10mg/mL, clear | [form ]
Solid | [pka]
13.10±0.20(Predicted) | [color ]
White to light yellow | [optical activity]
[α]/D +175 to +195°, c =1 in methylene chloride |
| Hazard Information | Back Directory | [Description]
GSK983 is a potent broad-spectrum antiviral. It blocks cell proliferation and dengue virus replication by inhibiting the pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase (DHODH). | [Uses]
GSK983 is a broad-spectrum antiviral agent. GSK983 inhibits the replication of adenovirus-5 (Ad-5) and polyoma virus SV40. GSK983 inhibits the growth of cell lines immortalized by
EBV, HTLV1, HPV. GSK983 induces the expression of interferon-stimulated genes[1]. | [References]
[1] Harvey R,et al. GSK983: a novel compound with broad-spectrum antiviral activity. Antiviral Res. 2009 Apr;82(1):1-11. DOI:10.1016/j.antiviral.2008.12.015 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|