| Identification | Back Directory | [Name]
DM4-Sme | [CAS]
796073-68-2 | [Synonyms]
DM4-Sme
Maytansinoid DM4 Impurity 1
Maytansinoid DM4 Impurity 1-d6
Maytansine, N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]- | [Molecular Formula]
C39H56ClN3O10S2 | [MDL Number]
MFCD28400104 | [MOL File]
796073-68-2.mol | [Molecular Weight]
826.46 |
| Chemical Properties | Back Directory | [Boiling point ]
963.8±65.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.82±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
LTLNAIFGVAUBEJ-GPEBISKRNA-N |
| Hazard Information | Back Directory | [Description]
DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2]. | [References]
[1]. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73.
[2]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). |
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