Identification | Back Directory | [Name]
PF-9366 | [CAS]
72882-78-1 | [Synonyms]
PF-9366 CS-2703 PF 9366 NEW PF-9366; PF 9366; PF9366;72882-78-1 [1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl- | [Molecular Formula]
C20H19ClN4 | [MDL Number]
MFCD31630724 | [MOL File]
72882-78-1.mol | [Molecular Weight]
350.84 |
Chemical Properties | Back Directory | [Melting point ]
182-183.5 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in DMSO (up to 20 mg/ml). | [form ]
solid | [pka]
8.75±0.28(Predicted) | [color ]
Beige | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Hazard Information | Back Directory | [Description]
PF-9366 (72882-78-1) is an allosteric inhibitor (IC50?= 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1?It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 μM and 225 nM respectively. | [Uses]
PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform. | [storage]
Store at -20°C | [References]
1) Quinlan?et al. (2017),?Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A; Nat. Chem. Biol.,?13?785 |
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