| Identification | Back Directory | [Name]
EPIMESTROL | [CAS]
7004-98-0 | [Synonyms]
Org 817
Stimovul
NSC 55975
EPIMESTROL
Estriol Impurity 11
3-Methoxy-17-epiestriol
3-Methoxyestra-1,3,5(10)-triene-16.α.,17.α.-diol
3-Methoxy)estra-1,3,5(10)-triene-16alpha,17alpha-diol
(8R,9S,13S,14S,16R,17S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-16,17-diol | [EINECS(EC#)]
230-278-0 | [Molecular Formula]
C19H26O3 | [MDL Number]
MFCD00198991 | [MOL File]
7004-98-0.mol | [Molecular Weight]
302.41 |
| Hazard Information | Back Directory | [Originator]
Stimovul,Organon,W. Germany,1976 | [Uses]
Anterior pituitary activator. | [Definition]
ChEBI: Epimestrol is a steroid. It derives from a hydride of an estrane. | [Manufacturing Process]
Reduction of 16-keto-17(α)-hydroxyestratrienol-3-methyl to 16,17-
dihydroxyestratrienol-3-methyl ether: A solution of 800 mg of the alpha ketol
methyl ether in 100 cc of ethanol and 10 cc of acetic acid was carefully
maintained at 40°C (water bath), and 200 g of freshly prepared sodium
amalgam (2%) were added in small pieces with efficient swirling. Before all ofthe amalgam had been added, a precipitation of sodium acetate occurred, and
at this point an additional 100 cc of 50% acetic acid were added. After all the
reducing agent had been added, the mixture was transferred to a separatory
funnel with ether and water. The mercury plus aqueous phase was separated,
after partitioning, from the ether; the latter may be further washed with
water, with 0.5N sodium hydroxide, and again with water to purify the alpha
glycol. Evaporation of the ethereal phase yielded a crystalline residue of the
isomeric transoid (16(β),17(α)-dihydroxy-steroid-3-methyl ether and cisoid
16(α),17(α)dihydroxy-steroid-3-methyl ether. | [Therapeutic Function]
Anterior pituitary activator |
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