| Identification | Back Directory | [Name]
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine | [CAS]
6975-75-3 | [Synonyms]
ILK-IN-3
1H-Pyrazole-3,5-diamine, 4-[2-(4-methoxyphenyl)diazenyl]-
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine
3-amino-4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazol-5-ylamine | [Molecular Formula]
C10H12N6O | [MDL Number]
MFCD01239326 | [MOL File]
6975-75-3.mol | [Molecular Weight]
232.24 |
| Chemical Properties | Back Directory | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO: 83.33 mg/mL (358.81 mM) | [form ]
Solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
QLT0267 is an orally activepotent and selective integrin-linked kinase (ILK) inhibitor (IC50 = 26 nM; selectivity: >1000-fold over CK2CSKDNA-PKPIM1PKB/AKTPKC>100-fold over ERK1GSK3βLCKPKAp70S6Kand RSK1/QLT>10-fold over CDK1/2/5) th at inhibits ILK-dependent cellular signaling (IC50 in 2h = 1 μM against 20 nM EGF-induced pAKT Ser473 phosphorylation in Hth74 cells). QLT0267 treatment causes thyroid cancer cell cycle arrest and apoptosisleading to anti-proliferation efficacy in cultures (IC50 <6 μM; NPA187DROand K4 cell lines) and in mice in vivo (DRO xenografts-derived tumor growth; 50-100 mg/kg via daily p.o.). | [storage]
Store at -20°C |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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