| Identification | Back Directory | [Name]
N-[4-(-Carboxycyclohexylmethyl)]maleimide | [CAS]
64987-82-2 | [Synonyms]
4-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)
4-(N-MaleiMidoMethyl)cyclohexanecarboxylic acid
4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 95%
4-((2,5-dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexanecarboxylic acid
4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]Cyclohexanecarboxylic acid
4-(Maleimidomethyl)cyclohexanecarboxylic Acid
(Discontinued, see C177860)
4-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylic acid | [Molecular Formula]
C12H15NO4 | [MDL Number]
MFCD03093740 | [MOL File]
64987-82-2.mol | [Molecular Weight]
237.25 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
157-158°C | [Boiling point ]
433.6±18.0 °C(Predicted) | [density ]
1.329±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform, Methanol | [form ]
Solid | [pka]
4.80±0.10(Predicted) | [color ]
Pale Yellow | [InChI]
InChI=1S/C12H15NO4/c14-10-5-6-11(15)13(10)7-8-1-3-9(4-2-8)12(16)17/h5-6,8-9H,1-4,7H2,(H,16,17) | [InChIKey]
LQILVUYCDHSGEU-UHFFFAOYSA-N | [SMILES]
C1(C(O)=O)CCC(CN2C(=O)C=CC2=O)CC1 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A sulfhydryl crosslinking reagent | [Uses]
An amino reactive reagent. | [Description]
4-((2,5-Dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexanecarboxylic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | [Definition]
N-(4-Carboxycyclohexylmethyl)maleimide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
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