| Identification | Back Directory | [Name]
AG 2263 | [CAS]
638213-98-6 | [Synonyms]
AG 2263
AGL 2263
Benzenepropanenitrile, α-[(2,3-dihydro-2-oxo-5-benzoxazolyl)methylene]-3,4-dihydroxy-β-oxo-, (αE)- | [Molecular Formula]
C17H10N2O5 | [MDL Number]
MFCD09037520 | [MOL File]
638213-98-6.mol | [Molecular Weight]
322.27 |
| Chemical Properties | Back Directory | [Melting point ]
210 °C | [density ]
1.541±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 2 mg/ml | [form ]
A crystalline solid | [pka]
7.47±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
AGL-2263 is an insulin receptor and insulin-like growth factor (IGF) receptor inhibitor[1][2]. | [References]
[1] Li Y, et al. GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5697-705. DOI:10.1073/pnas.1416675112
[2] Hua Zhang, et al. Somatic cells initiate primordial follicle activation and govern the development of dormant oocytes in mice. Curr Biol. 2014 Nov 3;24(21):2501-8. DOI:10.1016/j.cub.2014.09.023
[3] Ying Han, et al. Insulin mitigates apoptosis of porcine follicular granulosa cells by downregulating BimEL. Reprod Biol. 2019 Sep;19(3):293-298. DOI:10.1016/j.repbio.2019.08.003 |
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