| Identification | Back Directory | [Name]
2,2-DIMETHYLTHIOPROPIONAMIDE | [CAS]
630-22-8 | [Synonyms]
NSC 381432
Thiopivalamide
Neopentanethioamide
2,2-DIMETHYLTHIOPROPIOMIDE
2,2-DIMETHYLTHIOPROPIONAMIDE
2,2,2-Trimethylthioacetamide,
2,2,2-Dimethylthiopropionamide
Propanethioamide, 2,2-dimethyl- | [EINECS(EC#)]
677-829-5 | [Molecular Formula]
C5H11NS | [MDL Number]
MFCD09742834 | [MOL File]
630-22-8.mol | [Molecular Weight]
117.21 |
| Chemical Properties | Back Directory | [Melting point ]
117-119℃ (ethyl acetate hexane ) | [Boiling point ]
162.1±23.0℃ (760 Torr) | [density ]
0.978±0.06 g/cm3 (20 ºC 760 Torr) | [Fp ]
51.9±22.6℃ | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform, Ethyl Acetate | [form ]
Solid | [pka]
13.33±0.29(Predicted) | [color ]
White | [Water Solubility ]
Soluble in water (10 g/L) (25°C). | [InChI]
InChI=1S/C5H11NS/c1-5(2,3)4(6)7/h1-3H3,(H2,6,7) | [InChIKey]
FJZJUSOFGBXHCV-UHFFFAOYSA-N | [SMILES]
C(N)(=S)C(C)(C)C |
| Hazard Information | Back Directory | [Uses]
2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents). |
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