| Identification | Back Directory | [Name]
N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE-6-O-STEAROYL | [CAS]
60398-08-5 | [Synonyms]
Ac-(6-O-stearoyl)-muramyl-Ala-D-Glu-NH
6-o-stearoyl-n-acetylmuramyl-alanylisoglutamine
N-acetylmuramyl-6-O-stearoyl-L-alanyl-*D-isogluta
Ac-(6-O-stearoyl)-MuraMyl-Ala-D-Isogln-OH, L18-MDP
N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE-6-O-STEAROYL
N-ACETYLMURAMYL-6-O-STEAROYL-L-ALANYL-D-ISOGLUTAMINE)
D-α-Glutamine, N-[N-acetyl-6-O-(1-oxooctadecyl)muramoyl]-L-alanyl- | [Molecular Formula]
C37H66N4O12 | [MDL Number]
MFCD00134835 | [MOL File]
60398-08-5.mol | [Molecular Weight]
758.94 |
| Hazard Information | Back Directory | [Uses]
L18-MDP is a derivative of muramyl dipeptide, an antibacterial agent. L18-MDP has antibacterial activity and has potential applications in bacterial and fungal infections[1]. | [in vivo]
L18-MDP (100 μg; s.c.; single dose) has anti-infection effect in mice infected with Escherichia coli or Klebsiella pneumoniae[1].
L18-MDP (100 μg or 1000 μg; s.c., i.p., i.v. or p.o.; single dose) increases the survival rate of mice infected with Escherichia coli and improves the pathological tissue of mice infected with Listeria monocytogenes[1].
L18-MDP (100 μg or 200 μg; s.c. or i.p.; once daily for 3 days) increases the survival rate of mice infected with Candida albicans[1].
| Animal Model: | Mice infected with Escherichia coli, Klebsiella pneumoniae or Listeria monocytogenes[1]. | | Dosage: | 100 μg or 1000 μg. | | Administration: | Subcutaneous injection, intraperitoneal injection, intravenous injection or oral gavage; single dose. | | Result: | Strengthened the phagocytosis of the microorganisms, weakened the virus activity, increased the survival rate and improved the pathological tissue. |
| Animal Model: | Mice infected with Candida albicans[1]. | | Dosage: | 100 μg or 200 μg. | | Administration: | Subcutaneous injection or intraperitoneal injection; once daily for 3 days. | | Result: | Strengthened the phagocytosis of the microorganisms, weakened the virus activity, increased the survival rate and improved the pathological tissue. |
| [References]
[1] Osada Y, et al. Effect of L18-MDP(Ala), a synthetic derivative of muramyl dipeptide, on nonspecific resistance of mice to microbial infections. Infect Immun. 1982 Jul;37(1):292-300. DOI:10.1128/iai.37.1.292-300.1982 |
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