| Identification | Back Directory | [Name]
Promazine | [CAS]
58-40-2 | [Synonyms]
A-145
RP-3276
Wy-1094
Esparin
NSC 31447
Promazine
Sinophenin
Chlorpromazine-003
Promazine USP/EP/BP
Chlorpromazine impurity 1
Chlorpromazine Impurity 4
dimethyl(3-phenothiazin-10-ylpropyl)amine
Chlorpromazine hydrochloride EP Impurity C
PHENOTHIAZINE,10-(3-(DIMETHYLAMINO)PROPYL)-
10H-Phenothiazine-10-propanamine, N,N-dimethyl-
N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine
N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine
N,N-Dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine
Chlorpromazine Impurity 3(Chlorpromazine EP Impurity C) | [EINECS(EC#)]
200-382-0 | [Molecular Formula]
C17H20N2S | [MDL Number]
MFCD00242576 | [MOL File]
58-40-2.mol | [Molecular Weight]
284.419 |
| Chemical Properties | Back Directory | [Melting point ]
25°C | [Boiling point ]
bp0.3 203-210° | [density ]
1.1256 (rough estimate) | [refractive index ]
1.6000 (estimate) | [pka]
pKa 9.4(H2O,t =24±1) (Uncertain) | [Water Solubility ]
14.22mg/L(24 ºC) | [NIST Chemistry Reference]
Promazine(58-40-2) |
| Hazard Information | Back Directory | [Uses]
In psychiatric practice, promazine is used in minor cases of psychomotor excitement in
schizophrenics, in paranoid and manic-depressive conditions, for neurosis, alcoholic
psychosis, and others. It is sometimes used in anesthesiological practice. | [Uses]
ntipsychotic. | [Uses]
Promazine is an antipsychotic and a tranquilizer. | [Definition]
ChEBI: A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position. | [Brand name]
Sparine (Baxter Healthcare); Sparine (Wyeth). | [General Description]
Promazine, 10-[3-(dimethylamino) propyl-(phenothiazine monohydrochloride (Sparine), was introducedinto antipsychotic therapy after its 2-chloro-substitutedrelative. The 2H-substituent vis-à-vis the 2Clsubstituent gives a milligram potency decrease as an antipsychotic,as encompassed in Gordon’s rule. Tendency toEPS is also lessened, which may be significant, especially ifit is decreased less than antipsychotic potency. | [Synthesis]
Promazine, 10-(3-dimethylaminopropyl)phenothiazine (6.1.1), is prepared
by the alkylation of phenothiazine with 3-dimethylaminopropylchloride in the presence of
sodium amide [1¨C3].
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