| Identification | Back Directory | [Name]
Dicentrin | [CAS]
517-66-8 | [Synonyms]
Nsc406035
dicentrine
DICENTRINE95%
(S)-dicentrine
o,N-Dimethyllitseferine
1,2-Methylenedioxy-9,10-dimethoxyaporphine
9,10-Dimethoxy-1,2-(methylenedioxy)aporphine
1,2-(Methylenedioxy)-9,10-dimethoxy-6aalpha-aporphine
9,10-Dimethoxy-1,2-(methylenedioxy)-6aalpha-aporphine
6A.alpha.-Aporphine, 9,10-dimethoxy-1,2-(methylenedioxy)-
(7aS)-6,7,7a,8-Tetrahydro-10,11-dimethoxy-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline
5H-Benzo[G]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7A,8-tetrahydro-10,11-dimethoxy-7-methyl-, (S)-
5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline,6,7,7a,8-tetrahydro-10,11-dimethoxy-7-methyl-, (7aS)- | [Molecular Formula]
C20H21NO4 | [MDL Number]
MFCD00210492 | [MOL File]
517-66-8.mol | [Molecular Weight]
339.39 |
| Chemical Properties | Back Directory | [Melting point ]
177-178℃ | [Boiling point ]
481℃ | [density ]
1.266 | [refractive index ]
1.6250 (estimate) | [Fp ]
143℃ | [storage temp. ]
4°C, protect from light | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
6.65±0.20(Predicted) | [color ]
Off-white to light brown |
| Questions And Answer | Back Directory | [Description]
D-Dicentrine is an aporphinic alkaloid found in several plant species, mainly from family Lauraceae, including Lindera megaphylla. D-Dicentrine shows antinociceptive activity in a mouse model of pain. It probably acts via a TRPA1-dependent mechanism. D-Dicentrine is an alpha 1-adrenoceptor antagonist effective against human hyperplastic prostates.
| [Anti-cancer Activity]
D-Dicentrine, a naturally occurring aporphine type isoquinoline alkaloid, isolated from the root of Lindera megaphylla Hemsl. (Lauraceae), was evaluated for its potential anti-cancer activity. Huang RL etc. found d-dicentrine significantly inhibited the growth of human hepatoma cell line HuH-7 by delaying its doubling time in tissue culture. An in vitro colony forming assay showed that d-dicentrine decreased the colony formation efficiency in both hepatoma cell lines, HuH-7 and MS-G2, used in our study.
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| Hazard Information | Back Directory | [Uses]
d-Dicentrine is a natural aporphine alkaloid extracted from the root of L. megaphylla which displays antitumor effects through inhibition of topoisomerase II. | [Definition]
ChEBI: Dicentrine is an aporphine alkaloid. | [storage]
4°C, protect from light |
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