| Identification | Back Directory | [Name]
2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] | [CAS]
445222-91-3 | [Synonyms]
EMBL
MuRF1-IN-1
2-Amino-1'-methyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile
2'-amino-3'-cyano-1-methyl-1,3,5',6',7',8'-hexahydro-2,5'-dioxospiro[2H-indol-3,4'-(4'H)-chromene] | [Molecular Formula]
C18H15N3O3 | [MOL File]
445222-91-3.mol | [Molecular Weight]
321.33 |
| Chemical Properties | Back Directory | [Melting point ]
247-248 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
716.6±60.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (389.01 mM; Need ultrasonic) | [form ]
Solid | [pka]
2.42±0.20(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Biological Activity]
MuRF1-IN-1 is a muscle ring finger 1 (MuRF1) inhibitor that attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia[1]. | [storage]
Store at -20°C | [References]
[1]. Bowen TS, Adams V, Werner S, et al. Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):939-953. |
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://www.yuhua99.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
|
| Tel: |
|
| Website: |
www.sangon.com |
|