| Identification | Back Directory | [Name]
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide | [CAS]
420831-40-9 | [Synonyms]
AK-7
CS-922
AK 7, >=98%
AK-7;AK7;AK 7
SIRT2 Inhibitor II
SIRT2 Inhibitor,AK-7
SIRT2 Inhibitor II, AK-7
SIRT2 INHIBITOR II;AK7;AK 7
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide
Benzamide, N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-
N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide SIRT2 Inhibitor,AK-7 | [Molecular Formula]
C19H21BrN2O3S | [MDL Number]
MFCD03140195 | [MOL File]
420831-40-9.mol | [Molecular Weight]
437.35 |
| Chemical Properties | Back Directory | [density ]
1.469±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: ≥15mg/mL | [form ]
powder | [pka]
12.28±0.70(Predicted) | [color ]
white to tan | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
The sirtuin SIRT2 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates. It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer’s, Huntington’s, and Parkinson’s diseases. AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM). In culture, it diminishes neuronal cell death induced by mutant huntingtin fragment. In addition, AK-7 down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo. | [Uses]
AK-7 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates it is also a selective SIRT2 inhibitor. | [storage]
+4°C | [References]
1) Tylor et al. (2011), A brain-permeable small molecule that reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase; ACS Chem. Biol., 6 540
2) Chopra et al. (2012), The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington’s disease mouse models; Cell Rep., 2 1492 |
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