| Identification | Back Directory | [Name]
4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide | [CAS]
36707-00-3 | [Synonyms]
API-1
NSC 177223
4-Amino-5-oxo-8-pentofuranosyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide
Pyrido[2,3-d]pyrimidine-6-carboxamide, 4-amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-
4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide
4-amino-8-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide | [Molecular Formula]
C13H15N5O6 | [MOL File]
36707-00-3.mol | [Molecular Weight]
337.29 |
| Hazard Information | Back Directory | [Uses]
NSC 177223 is a Akt/protein kinase B inhibitor. It binds to pleckstrin homologous domain of Akt and blocks Akt membrane translocation. Treatment of cancer cells with NSC 177223 results in inhibition o
f the kinase activities and induction of cell growth arrest and apoptosis selectively in human cancer cells that harbor constitutively activated Akt. | [Biological Activity]
API-1 is a potent and specific Akt/PKB inhibitor. API-1 binds to pleckstrin homology (PH) domain of Akt and blocks Akt membrane translocation. The compound inhibits all three members of the family Akt1/PKBaAkt2/PKBb and Akt3/PKBg. API-1 does not inhibit the activation of PKCSGKPKASTAT3Erk-1/2 or JNK. | [storage]
Store at -20°C |
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Lynnchem
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http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
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44-20819178-90 02081917890 |
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https://www.novachemistry.com/ |
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