| Identification | Back Directory | [Name]
2-amino-N-(2,2,2-trifluoroethyl)acetamide | [CAS]
359821-38-8 | [Synonyms]
2-amino-N-(2,2,2-trifluoroethyl)acetamide
Acetamide, 2-?amino-?N-?(2,?2,?2-?trifluoroethyl)?- | [Molecular Formula]
C4H7F3N2O | [MDL Number]
MFCD09944516 | [MOL File]
359821-38-8.mol | [Molecular Weight]
156.11 |
| Chemical Properties | Back Directory | [Boiling point ]
227.5±40.0 °C(Predicted) | [density ]
1.294±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
12.87±0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
2-amino-N-(2,2,2-trifluoroethyl) acetamide, which is usually stable in the form of salt, is a key intermediate in the synthesis of fluralaner, a new broad-spectrum veterinary insecticide. | [Preparation]
The method of preparing 2-amino-N-(2,2,2-trifluoroethyl) acetamide and its salt is to react the glycine protected by N-phthalyl group with trifluoroethylamine or its salt to form an amide, and remove the protective group under the action of hydrated fibril to obtain the crude product of 2- amino-N-(2,2,2-trifluoroethyl) acetamide.The crude product can be salted with acid to get a salt of 2-amino-N-(2,2, 2-trifluoroethyl) acetamide, and finally add a base to dissociate pure 2-amino-N-(2,2, 2-trifluoroethyl) ethylkuroamine.
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